Clinical efficacy observation of batroxobin combined with ginaton injection solution in the treatment of patients with sudden deafness and dizziness
Objective To investigate the clinical efficacy of batroxobin(BX)combined with ginaton injection solution(GIS)in patients with sudden deafness with vertigo(SDV).Methods SDV patients admitted to Yan'an City People's Hospital from April 2020 to January 2023 were retrospectively selected as study subjects,and were divided into the BX group(dexamethasone combined with BX)and the GIS group(dexamethasone combined with BX and GIS)based on the different treatment programs of the patients.The clinical efficacy,hearing recovery time,tinnitus relief time and vertigo relief time of the two groups were compared.The occurrence of adverse reactions during treatment were observed and compared.The levels of serum inflammatory factors[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(Hs-CRP),interleukin-6(IL-6)]before and after treatment in the two groups were compared.Results A total of 90 patients with SDV were included in the study,49 and 41 in the GIS and BX groups,respectively.The total effective rate of treatment in the GIS group was significantly higher than that in the BX group(P<0.05).The time for hearing restoration,when tinnitus was relieved,and the time for vertigo to be relieved in the GIS group was significantly shorter than that in the BX group(P<0.05).The total effective rate of treatment in the GIS group was significantly higher than that in the BX group(P<0.05).Before treatment,the differences in serum TNF-α,Hs-CRP and IL-6 between the two groups were not statistically significant(P>0.05);after treatment,the levels of serum TNF-α,Hs-CRP and IL-6 in the two groups were significantly lower than those before treatment(P<0.05);and the levels in the GIS group were lower than those in the BX group(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion The efficacy of GIS combined with BX in the treatment of SDV patients is remarkable,which can shorten the time of hearing recovery,tinnitus relief and vertigo relief of the patients,which may be related to the reduction of the level of inflammation in the body by GIS and BX.
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