中国药师2024,Vol.27Issue(3) :536-544.DOI:10.12173/j.issn.1008-049X.202401027

1例蜡样芽孢杆菌导致中枢神经系统感染的案例报告并文献复习

Central nervous system infection caused by Bacillus cereus:a case report and literature review

黄钰茹 刘浩 崔彦 俞淼
中国药师2024,Vol.27Issue(3) :536-544.DOI:10.12173/j.issn.1008-049X.202401027

1例蜡样芽孢杆菌导致中枢神经系统感染的案例报告并文献复习

Central nervous system infection caused by Bacillus cereus:a case report and literature review

黄钰茹 1刘浩 2崔彦 3俞淼3
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作者信息

  • 1. 重庆医科大学附属大足医院药剂科(重庆 402360)
  • 2. 重庆医科大学附属第一医院药学部(重庆 400042)
  • 3. 重庆市第五人民医院药剂科(重庆 400062)
  • 折叠

摘要

本文报告1例颅内肿瘤患者感染蜡样芽孢杆菌(Bacillus cereus)的诊疗过程,收集 43 例已报道的蜡样芽孢杆菌导致中枢神经系统(CNS)感染的案例,同时复习国内外相关文献,对蜡样芽孢杆菌导致CNS感染的临床表现、治疗方案等进行分析,为临床治疗蜡样芽孢杆菌导致的CNS感染提供借鉴.该类感染在血液恶性肿瘤、早产儿、颅内恶性肿瘤、中心粒细胞减少症的患者中较为多见,应尽早选用万古霉素、美罗培南等敏感且易透过CNS的抗菌药物进行治疗.蜡样芽孢杆菌在临床常被当作污染菌,近年来其导致的感染案例报道越来越多.在易感人群中应高度警惕,尽早开始经验治疗,以改善预后.

Abstract

The diagnosis and treatment process of a patient with intracranial tumor infected with Bacillus cereus was reported in this article,a total of 43 reported cases of central nervous system(CNS)infection caused by Bacillus cereus were collected,and the relevant literature at home and abroad was reviewed to analyze the clinical manifestations and treatment regimens of CNS infection caused by Bacillus cereus,providing references for clinical treatment of CNS infection caused by Bacillus cereus.This type of infection is more common in patients with hematologic malignancies,premature infants,intracranial malignancies,and central granulocytopenia,and sensitive and easily transmissible CNS antibiotics,such as vancomycin and meropenem should be selected for treatment as early as possible.Bacillus cereus is often regarded as a contaminating bacterium in clinical practice.However,in recent years,more and more cases of infection caused by Bacillus cereus have been reported.High vigilance should be emphasized in susceptible populations to start empirical treatment as early as possible to improve the prognosis.

关键词

蜡样芽孢杆菌/中枢神经系统/感染/抗感染治疗/案例报告/文献复习

Key words

Bacillus cereus/Central nervous system/Infection/Anti infection treatment/Case report/Literature review

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基金项目

重庆市南岸区科卫联合医学科研项目(2021-02)

出版年

2024
中国药师
国家药品监督管理局高级研修学院,武汉医药(集团)股份有限公司

中国药师

CSTPCD
影响因子:0.944
ISSN:1008-049X
参考文献量47
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