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羧甲司坦含量测定方法的研究进展

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羧甲司坦是一种常用的祛痰药物,目前已报道的羧甲司坦检测方法主要有电化学法、溴酸钾滴定法、动力学法、光谱法、色谱法、柱前衍生高效液相色谱荧光法、液相-质谱联用法等,该文对比分析了各种分析方法的优缺点,发现HPLC法更适合羧甲司坦质量分析,为提升羧甲司坦检测标准提供参考。
Research progress on determination methods of carbocisteine
Carbocisteine is a commonly used expectorant drug.Currently,the reported detection methods for carbocisteine mainly include the electrochemical method,potassium bromated titration,kineticmethod,spectrometry,chromatography,HPLC-FLD precolumn derivation determination,HPLC-MS,etc.The advantages and disadvantages of each method were compared and analyzed in this paper,and it is found that HPLC was more suitable for the quality analysis of carbocisteine,which could serve as a reference for upgrading standard of carbocisteine content determination.

CarbocisteineDeterminationSpectrometryChromatographyChronic obstructive pulmonary diseaseDispelling phlegmResearch progress

辛昱轩、秦咏九、徐新元

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徐汇食品药品检验所(上海 200030)

羧甲司坦 含量测定 光谱法 色谱法 慢性阻塞性肺病 祛痰 研究进展

2024

中国药师
国家药品监督管理局高级研修学院,武汉医药(集团)股份有限公司

中国药师

CSTPCD
影响因子:0.944
ISSN:1008-049X
年,卷(期):2024.27(5)
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