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国内抗体药物安全性及风险研究的CiteSpace文献计量分析

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目的 分析近10年国内抗体药物安全性及风险研究的发展现状、最新的研究热点及前沿。方法 利用CiteSpace 6。2。R2软件分析2012-2022年CNKI、万方、VIP数据库中抗体药物安全性及风险相关的全部文献。结果 3个数据库共获得2 773篇文献,去重后导入CiteSpace,最后纳入分析的文献1 870篇,近10年来抗体药物安全性与风险研究领域发文量在2012-2019年维持在每年100篇左右,自2020年以后文章发表数量开始攀升,在2021-2022年年发文量增长至300篇左右;国内机构合作网络图谱显示,抗体药物安全性及风险研究的各研究机构之间缺乏合作,主要是医院在进行该领域的研究,研究主体类型相对单一。作者合作网络图谱显示,以李波、杨艳伟、林志等所在团队为该研究领域的核心团队合作最为紧密,而高产作者之间合作较少,另外有部分专家学者是以个人或小团体独自进行研究,研究热点集中在不良反应、安全性、贝伐珠单抗、利妥昔单抗、Meta分析等方面。结论 国内近10年主要集中于研究抗体药物的临床有效性与安全性方面,鲜有学者研究探讨关于抗体药物的风险。因此,未来有待关注和重视对抗体药物风险方面的研究。
CiteSpace bibliometric analysis of safety and risk studies of antibody drugs in China
Objective To analyze the domestic antibody drug safety and risk research status,the latest research hotspots and frontiers in the current ten years.Methods CiteSpace 6.2.R2 software was used to analyze all literature related to the safety and risk of antibody drugs in CNKI,WanFang data and Vip database from 2012 to 2022.Results A total of 2 773 pieces of literature were obtained from the three databases,which were imported into CiteSpace after deduplication,and finally,1 870 pieces were included in the analysis.In the past decade,the number of articles published in the field of antibody drugs safety and risk research has remained at about 100 articles per year from 2012 to 2019,since 2020,the number of articles published has started to increase,and the annual number of articles published has increased to around 300 articles from 2021 to 2022.The network graph of domestic institutional cooperation showed that there was a lack of cooperation among the research institutions of antibody drug safety and risk research,mainly due to the fact that hospitals were conducting research in this field,and the types of research subjects were relatively single.The author collaboration network graph showed that the core teams in this research field,such as Li Bo,Yang Yanwei,and Lin Zhi,had the closest collaboration,while there was less collaboration among high-yield authors,additionally,some experts and scholars conducted research on their own as individuals or small groups,the research focused on adverse reactions,safety,bevacizumab,Rituximab,Meta-analysis,etc.Conclusion In the past decade,domestic research has mainly focused on the clinical efficacy and safety of antibody drugs,with few scholars exploring the risk of antibody drugs,therefore,in the future,it is necessary to pay attention to the research on the risks of antibody drugs.

Antibody drugsCiteSpaceSafetyRiskAdverse reactionsBibliometricsDrug safetyRisk management

彭月、刘玲玲、蔡沅璇、赵宇航、上官小芳、李康玲、陈哲锐、李克、黄锐、卢圆圆

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武汉科技大学医学院药学系(武汉 430065)

湖北省妇幼保健院药学部(武汉 430070)

华中科技大学同济医学院药学院(武汉 430030)

中南财经政法大学统计与数学学院(武汉 430073)

武汉药品医疗器械检验所(武汉 430073)

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抗体药物 CiteSpace 安全性 风险 不良反应 文献计量学 药物安全 风险管理

药物制剂质量研究与控制重点实验室开放课题资助项目湖北省药品监督管理局药品安全监管科研项目

YWZJZD-20220220220112

2024

中国药师
国家药品监督管理局高级研修学院,武汉医药(集团)股份有限公司

中国药师

CSTPCD
影响因子:0.944
ISSN:1008-049X
年,卷(期):2024.27(6)