Prevention effect of ceftriaxone sodium combined with bundle management on early ventilator-associated pneumonia
Objective To observe the preventive effect of ceftriaxone sodium(CRO)combined with bundle management(BM)on early ventilator-associated pneumonia(VAP)in the intensive care unit(ICU)patients with mechanical ventilation(MV).Methods A total of 138 ICU patients treated with MV at Beijing Tongren Hospital affiliated to Capital Medical University were selected from May 2022 to April 2023.According to whether CRO was used,they were divided into CRO group and non-CRO(NCRO)group,and BM was performed during hospitalization in both groups.The incidence of early VAP,mortality,duration of mechanical ventilation,ICU stay,and total hospital stay were observed and compared between the two groups.In addition,the changes in inflammatory indicators[C-reactive protein(CRP),procalcitonin(PCT),and white blood cell count(WBC)]were compared before and after the intervention(on day 7).Results The incidence of early VAP was lower in the CRO group than in the NCRO group(P＜0.05).The mortality rate of patients in the CRO group was lower than that in the NCRO group,but the difference was not statistically significant(P＞0.05).The duration of mechanical ventilation,length of ICU stay and total hospital stay in the CRO group were shorter than those in the NCRO group(P＜0.05).Before treatment,the CRP levels,serum PCT levels,and WBC were not significantly different between the two groups(P＞0.05).Compared with before treatment,serum CRP levels,PCT levels and WBC were significantly decreased in the CRO and NCRO groups(P＜0.05).In addition,serum CRP,PCT and WBC of the CRO group were lower than the NCRO group on the seventh day,with a statistically significant difference(P＜0.05).Conclusion CRO combined with BM can reduce the incidence of early VAP in ICU patients undergoing MV,shorten MV time,ICU stay and total hospital stay,and reduce the level of inflammatory response.
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