Clinical efficacy of Qingpeng unguentum combined with auricular acupuncture and multi-dimensional collaborative intervention in patients with postherpetic neuralgia
Objective To explore the clinical efficacy of Qingpeng unguentum(QU)combined with auricular acupuncture(AA)and multi-dimensional collaborative intervention(MDCI)in the treatment of postherpetic neuralgia(PHN).Methods Patients with PHN who attended the department of dermatology at Zhejiang Provincial Dermatology Hospital from January 2022 to January 2023 were retrospectively selected.According to the intervention regimens,patients were divided into three groups:the QU group(QU external application),the AA group(QU external application combined with AA),and the MDCI group(QU external application combined with AA and MDCI).Changes in negative mood[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)],pain degree(visual analogue scale,VAS score),sleep quality(Pittsburgh sleep quality index,PSQI score),quality of life(mos36-item short form health survey,SF-36 score)and inflammatory markers(IL-6,TNF-α and CRP)were compared before and after intervention using paired sample t-tests.Differences among the groups in these parameters and in nursing satisfaction were analyzed using ANOVA,rank-sum test,or chi-square test.Results A total of 110 PHN patients were included in this study,with 30 in the QU group,41 in the AA group,and 39 in the MDCI group.There were no significant differences among the three groups in negative mood,pain degree,sleep quality,quality of life,and inflammatory markers(P>0.05).After 1 month of intervention,the scores for SAS,SDS,VAS,PSQI,as well as serum levels of IL-6,TNF-α,and CRP,significantly decreased compared to pre-intervention levels(P<0.05).The level of these indicators were lower in the AA group than in the QU group(P<0.05),and the level in the MDCI group were lower than those in the AA group(P<0.05).SF-36 scores were elevated in the 3 groups compared with the pre-intervention period,and were greater in the MDCI group than in the AA group,and in the AA group than in the QU group(P<0.05).Additionally,the total response rate and total satisfaction rate were significantly higher in the AA group than in the QU group(P<0.05),and higher in the MDCI group than in the AA group(P<0.05).Conclusion QU combined with AA and MDCI significantly improves negative mood,pain degree,sleep quality,and quality of life in PHN patients,reduces levels of inflammatory markers,and enhances overall treatment efficacy.It is recommended for promotion in clinical practice.
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