目的 探讨吡咯喹啉醌(PQQ)的研究热点与发展趋势，挖掘PQQ的研究及应用价值。方法 本研究以Web of Science为检索的数据库，检索1985年至2022年发表的关于PQQ的文献，采用VOSviewer纳入文献的关键词、国家及地区、期刊等，对这些文献进行文献计量学分析。结果 共纳入1512篇文献，年发文量整体呈现上升的趋势。发文量排名最高的期刊类别为Biochemistry Molecular Biology;引文期刊Journal of Biological Chemistry总链接强度最大;高频关键词主要包括膳食营养补充剂、线粒体、抗氧化等;国家及地区可视化结果显示中国虽然研究开始的时间较晚，但是与其他国家链接强度较大。结论 近年来，对于PQQ的研究热度逐渐上升，其抗氧化作用、改善线粒体功能以及作用靶点可能是未来研究的热点。PQQ仍然具有广阔的发展前景，为医药健康产业注入新的活力。
Bibliometric and visualization analysis of pyrroloquinoline quinone research from 1985 to 2022
Objective To explore the research hotspots and development trends of pyrroloquinoline quinone(PQQ),and explore the research and application value of PQQ.Methods In this study,Web of Science was used as the retrieval database to search for literature related to PQQ published from 1985 to 2022,and VOSviewer software was used to include the keywords,countries and regions,journals,etc.Bibliometric analysis was performed on these literatures.Results A total of 1 512 articles were included,with an overall upward trend in the number of annual publications.The journal category with the highest number of publications was Biochemistry and Molecular Biology.Journal of Biological Chemistry had the highest total link strength.The high-frequency keywords mainly included dietary nutrition supplement,mitochondria,antioxidant,etc.The visualization results of countries and regions showed that although China started its research relatively late,and it had a strong connection intensity with other countries.Conclusion In recent years,the research heat of PQQ has gradually increased,and its antioxidant effects,improvement of mitochondrial function and action targets may be the hotpots of future research.PQQ still has broad development prospects,and will inject new vitality into the pharmaceutical and healthcare industry.
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