摘要
爵床主要含有木脂素、黄酮、生物碱等类型的化学成分,临床上常用于辅助治疗疟疾、热病、肺热咳嗽、毒蛇咬伤等疾病.现代药理研究表明其具有抗血小板聚集、镇痛、抗肿瘤和抗炎等多种药理作用.本综述对爵床的本草考证进行了更具体的归纳,并结合国内外研究对爵床的化学成分、药理作用以及临床应用进行了总结,基于"五原则"及网络药理学、传统药性对爵床的质量标志物(Q-Marker)进行预测分析.初步预测6'-羟基爵床脂定A、6'-羟基爵床脂定B、6'-羟基爵床脂定C、爵床脂定B、金不换甲醚、山奈酚等成分可作为爵床的Q-Marker,以期为更好地开发和利用爵床属植物资源提供借鉴.
Abstract
The chemical constituents of Justicia procumbens are mainly lignans,flavonoids,alkaloids,etc.It is commonly used in clinical practice as an adjunctive treatment for malaria,fevers,coughs of pulmonary fever,poisonous snake bites and other diseases.Modern pharmacological studies have shown that Justicia procumbens has anti-platelet aggregation,analgesic,anti-tumor and anti-inflammatory effects.In this review,the herbal evidence of Justicia procumbens was summarised in more detail,and the chemical composition,the pharmacological effects and clinical applications of Justicia procumbens were summarised in combination with domestic and international studies,and the quality marker(Q-Marker)of Justicia procumbens was predicted and analyzed on the basis of the Five Principles,network pharmacology,and traditional medicinal properties.The preliminary predictions of 6'-hydroxy justicidin A,6'-hydroxy justicidin B,6'-hydroxy justicidin C,justicidin B,Chinensinaphthol methyl ether,and kaempferol were used as the Q-Markers of Justicia procumbens with a view to provide a reference for the better development and utilisation of Justicia resources.
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