首页|中药滚蛋疗法治疗小儿腹泻的近远期临床效果分析

中药滚蛋疗法治疗小儿腹泻的近远期临床效果分析

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目的 探究中药滚蛋疗法治疗在小儿腹泻治疗中的应用效果。方法 回顾性分析东莞市人民医院2022年4月至2024年4月腹泻患儿临床资料,按照治疗方法分为对照组和联合组。对照组予以西药治疗,联合组在对照组基础上联合中药滚蛋疗法治疗,7 d为一个疗程,共治疗两个疗程。评价临床疗效,对比治疗后临床症状变化时间,观察治疗前后肠道菌群水平、免疫功能[免疫球蛋白(Ig)A、IgG、IgM]、炎症因子[白细胞介素(IL)-6、IL-17、肿瘤坏死因子(TNF)-α]水平差异,分析治疗安全性及6个月内复发情况。结果 研究共纳入患者180例,对照组106例,联合组74例。联合组总有效率高于对照组(P<0。05)。治疗后,联合组止泻、退热及大便性状变为正常的时间均低于对照组(P<0。05),两组双歧杆菌、乳酸杆菌数量均高于治疗前,且联合组高于对照组(P<0。05);两组肠球菌数量及TNF-α、IL-6、IL-17水平均低于治疗前,且联合组低于对照组(P<0。05);联合组IgA、IgG与IgM水平较治疗前均升高,且IgA水平显著高于对照组(P<0。05)。6个月时,联合组复发率低于对照组(P<0。05)。结论 中药滚蛋疗法联合西药治疗小儿腹泻的近、远期疗效确切,其作用机制可能与改善机体免疫功能、炎症反应及肠道菌群相关。
Analysis of short-and long-term clinical effect of traditional Chinese medicine rolling egg therapy in treating infantile diarrhea
Objective To explore the application effect of traditional Chinese medicine rolling egg therapy in the treatment of infantile diarrhea.Methods A retrospective analysis was conducted on the clinical data of children with diarrhea in Dongguan People's Hospital from April 2022 to April 2024.According to the treatment methods,they were divided into the control group and the combination group.The control group was treated with western medicine,while the combination group was combined with traditional Chinese medicine rolling egg therapy on the basis of the control group.7 d was a course of treatment,and a total of 2 courses of treatment was conducted.The clinical efficacy was evaluated,and the durations of clinical symptom changes after treatment were compared.The intestinal flora,immune function[immunoglobulin (Ig) A,IgG,IgM]and inflammatory factors[interleukin (IL)-6,IL-17,tumor necrosis factor (TNF) α]were observed before and after treatment.The treatment safety was analyzed,and the recurrence within 6 months of follow-up was counted.Results A total of 180 patients were included in the study,with 106 in the control group and 74 in the combination group.The total effective rate of the combination group was higher than that of the control group (P<0.05).After treatment,the time to stop diarrhea,reduce fever and change stool properties to normal in the combination group was lower than that in the control group (P<0.05);the number of Bifidobacteria and Lactobacilli in both groups was higher than that before treatment,and the number of combination group was higher than that of the control group (P<0.05);the number of Enterococcus faecalis and the levels of TNF-α,IL-6 and IL-17 were lower than those before treatment in both groups,and these in the combination group were lower than those in the control group (P<0.05);the levels of IgA,IgG and IgM were higher than those before treatment in the combination group (P<0.05),and the IgA level was significantly higher than that of the control group (P<0.05).At 6 months,the recurrence rate of the combination group was lower than that of the control group (P<0.05).Conclusion Traditional Chinese medicine rolling egg therapy combined with western medicine is effective in the treatment of children with diarrhea,and its mechanism may be related to the improvement of immune function,inflammatory response and intestinal flora.

Integration of traditional Chinese and western medicineInfantile diarrheaRolling egg therapyInflammatory factorsLong-term efficacyImmunoglobulinTumor necrosis factorClinical effect

黄玉霞、罗丽娇、袁慧珍、祝逢景、蔡淑君

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南方医科大学第十附属医院(东莞市人民医院)小儿内科,广东东莞523000

中西结合疗法 小儿腹泻 滚蛋疗法 炎症因子 远期疗效 免疫球蛋白 肿瘤坏死因子 临床疗效

2024

中国药师
国家药品监督管理局高级研修学院,武汉医药(集团)股份有限公司

中国药师

CSTPCD
影响因子:0.944
ISSN:1008-049X
年,卷(期):2024.28(10)