新型抗VEGF疗法在新生血管性年龄相关性黄斑变性中的研究进展
Research progress of novel anti-VEGF therapy in the treatment of neovascular age-related macular degeneration with novel drugs
侯慧敏 1常雪柯 1张乐颖 2宋宗明3
作者信息
- 1. 郑州大学人民医院眼科,郑州 450003;河南省人民医院眼科,郑州 450003;河南省立眼科医院眼科,郑州 450003
- 2. 河南省人民医院眼科,郑州 450003;河南省立眼科医院眼科,郑州 450003;河南大学人民医院眼科,郑州 450003
- 3. 郑州大学人民医院眼科,郑州 450003;河南省人民医院眼科,郑州 450003;河南省立眼科医院眼科,郑州 450003;河南大学人民医院眼科,郑州 450003
- 折叠
摘要
新生血管性年龄相关性黄斑变性(nAMD)是导致中老年人视力损害的主要原因之一,且该疾病的发生率在我国呈上升趋势.血管内皮生长因子(VEGF)失调是导致nAMD的主要原因.此外,除VEGF之外的多种生长因子、补体系统活化、炎症因素、自噬等多种因素也参与了nAMD的发病过程.目前,玻璃体腔内注射抗VEGF药物已成为治疗nAMD的一线方案,但当前的抗VEGF药物仍存在许多不足,如频繁的注射存在多种潜在风险、部分患者反应不敏感、患者的依从性低等,因此寻找新型治疗药物已迫在眉睫.本文对新上市和正在进行临床试验的新型药物在治疗nAMD方面的研究新进展进行综述,旨在寻求药效更持久、作用更好的治疗方案,并探索新的治疗靶点,进一步为推动nAMD治疗策略的创新与发展提供参考.
Abstract
Neovascular age-related macular degeneration (nAMD) is one of the main causes of visual impairment in middle-aged and elderly people,and the incidence of this disease is rising in our country.The imbalance of vascular endothelial growth factor (VEGF) is the main cause of nAMD.In addition,various growth factors other than VEGF,complement system activation,inflammatory factors,autophagy,and many other factors are involved in the pathogenesis of nAMD.Currently,intravitreal injection of anti-VEGF drugs has become the first-line regimen for the treatment of nAMD,but there are still many shortcomings of the current anti-VEGF drugs,such as multiple potential risks of frequent injections,insensitive responses in some patients,and low compliance of the patients,etc.Therefore,the search for novel therapeutic agents has become urgent.This article provides a review of new developments in the study of novel drugs newly marketed and undergoing clinical trials for the treatment of nAMD,with the aim of seeking longer-lasting and better-acting therapeutic regimens,as well as exploring new therapeutic targets,to further inform the advancement of innovation and development of therapeutic strategies for nAMD.
关键词
新生血管性年龄相关性黄斑变性/发病机制/新型药物Key words
Neovascular age-related macular degeneration/Pathogenesis/Novel drugs引用本文复制引用
出版年
2024
NETL
NSTL
万方数据