染料木素抗阿尔茨海默病的机制研究进展
Research progress on the mechanism of genistein in Alzheimer's disease
赵明勇 1凌迎春 2李玲玲 3钟芳芳4
作者信息
- 1. 绍兴文理学院医学院附属精神卫生中心精神科,浙江绍兴 312000
- 2. 绍兴文理学院医学院附属精神卫生中心检验科,浙江绍兴 312000
- 3. 绍兴文理学院医学院附属精神卫生中心产科,浙江绍兴 312000
- 4. 绍兴文理学院附属医院/绍兴人民医院神经内科,浙江绍兴 312000
- 折叠
摘要
随着世界人口的老龄化,阿尔茨海默病(AD)的发病率不断上升.目前,AD已成为现代医学面临的最严重问题之一.染料木素是一种黄酮类的植物活性物质,由于其结构与雌激素相似,可以模拟雌激素的作用,具有多种生物活性,因其具有多途径靶向性和低毒性等特点,被认为是AD的一种有效的潜在治疗药物.本文对染料木素的药动学进行介绍,并从其类雌激素作用、抗氧化、抗炎、抗β-淀粉样蛋白、调节胆碱能神经传递和抑制Tua蛋白磷酸化等多个方面对染料木素在AD中的神经保护作用及作用机制进行综述.
Abstract
With the aging of the world's population,the incidence of Alzheimer's disease (AD) is continuously increasing.Currently,AD has become one of the most severe challenges faced by modern medicine.Genistein is a flavonoid phytoactive substance,whose structure is similar to that of estrogen,allowing it to mimic the effects of estrogen and possess various biological activities.Due to its multi-pathway targeting and low toxicity characteristics,it is considered to be an effective potential therapeutic source for AD.In this paper,the pharmacokinetics of genistein are introduced,and its neuroprotective effects and mechanisms in AD are reviewed from the aspects of its estrogen-like action,antioxidant,anti-inflammatory,anti-β-amyloid,regulation of cholinergic neurotransmission and inhibition of Tau protein phosphorylation.
关键词
染料木素/植物活性药物/阿尔茨海默病/神经保护/雌激素/研究进展Key words
Genistein/Phytoactive drugs/Alzheimer's disease/Neuroprotective/Estrogen/Research progress引用本文复制引用
出版年
2024
NETL
NSTL
万方数据