中药辐照灭菌研究进展
Research progress on irradiation sterilization of traditional Chinese medicine
杨晨 1郑玉霄 1胥新元 1李跃辉1
作者信息
- 1. 湖南省中医药研究院,长沙 410013;湖南中医药大学,长沙 410208
- 折叠
摘要
灭菌是中药生产的关键环节之一,更是确保中药安全、有效、质量可控的重要因素.传统灭菌技术如湿热灭菌等在诸多情况下因自身固有的缺点而受到限制.相比之下,辐照灭菌法凭借其快捷、高效、杀菌力强以及成本低等优势,日益受到人们的关注.然而,由于辐照具有放射性及强穿透性,中药化学成分复杂,在经一定剂量辐射后,其化学成分与药理活性等可能会发生变化.但目前,对于中药辐照灭菌后化学成分变化、有效性和安全性尚缺乏系统研究.本文结合近年来60Co-γ射线和电子束辐照灭菌在中药灭菌研究的现状,综述辐照对中药有效性的影响、辐照的检测方法以及安全性评价等,以期为后续中药辐照灭菌的应用提供一定的参考.
Abstract
Sterilization is one of the key links in the production of traditional Chinese medicine,and it is also an important factor to ensure the safety,effectiveness and quality control of traditional Chinese medicine.Traditional sterilization techniques such as moist heat sterilization are limited in many cases due to their inherent shortcomings.In contrast,irradiation sterilization has attracted more and more attention due to its advantages of fast,efficient,strong sterilization and low cost.However,the chemical composition of traditional Chinese medicine is complex,due to the radioactivity and strong penetration of irradiation,after a certain dose of irradiation,its chemical composition and pharmacological activity may change.At present,there is still a lack of systematic research on the changes of chemical composition,effectiveness and safety of traditional Chinese medicine after irradiation sterilization.Based on the research status of 60Co-γ ray and electron beam irradiation sterilization in the sterilization of traditional Chinese medicine in recent years,this paper reviews the effects of irradiation on the effectiveness of traditional Chinese medicine,the detection methods of irradiation and the safety evaluation,in order to provide some reference for the subsequent application of irradiation sterilization of traditional Chinese medicine.
关键词
辐照灭菌/60Co-γ射线/电子束/中药/微生物/化学成分/有效性Key words
Irradiation sterilization/60Co-γ ray/Electron beam/Traditional Chinese medicine/Microorganisms/Chemical constituents/Effectiveness引用本文复制引用
出版年
2024
NETL
NSTL
万方数据