Preparation process and transdermal absorption of fusidic acid film
Objective To optimize the prescription of fusidic acid film and study its transdermal absorption behavior. Methods The fusidic acid film was evaluated comprehensively based on the film-forming time,toughness,peelability,and viscosity. On the basis of single-factor experiments,response surface design experiments were used to optimize the prescription. HPLC was used for quality control of the fusidic acid film. The improved Franz diffusion cell apparatus was used to study the transdermal absorption behavior of the fusidic acid film. Results The response surface design experiments yielded a prescription with good properties,consisting of 4.8％ polyvinyl butyral,1.9％ hydroxypropyl methylcellulose MF,2.0％ triethyl citrate and 89.3％ anhydrous ethanol. The 24-hour cumulative permeation rate was 87.74％,which was significantly better than that of commercially available fusidic acid cream. Conclusion This experiment identified the optimal ratio and dosage of the prescription for fusidic acid film. The new formulation is of stable and controllable quality,providing a basis for the clinical use of fusidic acid film.
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