Effect of administration with different doses of naloxone on puerpera and neonatal infants before intraspinal anesthesia
Objective To investigate the effects of different doses of naloxone (NAL) administered on the puerpera and the newborn before intraspinal anesthesia. Methods The clinical data of women who underwent intraspinal labor analgesia at The Second Affliated Hospital of Shantou University Medical College from August 2020 to June 2023 were analyzed. The patients were divided into three groups according to the dose of NAL given before intraspinal anesthesia:the control group (NAL 0 μg),the NAL-A group (NAL 40 μg),and the NAL-B group (NAL 80 μg). The observed indicators include the puerpera's condition (VAS score,PCA button presses,labor duration,complication incidence),and the newborn's condition (weight,Apgar score,umbilical artery blood pH value,PCO2 and PO2). Results A total of 236 puerpera were included in the study,with 77 in the NAL-A group,79 in the NAL-B group,and 80 in the control group. Maternal VAS scores and the number of PCA presses gradually decreased with the increasing NAL dose (P<0.05). The first stage of labor,the second stage of labor,and the incidence of adverse reactions in the NAL-B group were significantly lower than those of the NAL-A group and the control group (P<0.05). The weights of the newborns,Apgar scores,umbilical artery blood pH,PCO2 and PO2 were not statistically significant in the three groups (P>0.05). Conclusion 80 μg NAL administered before intraspinal anesthesia is more effective,which can shorten the duration of labor,reduce the incidence of adverse effects,and has less effect on the newborn.
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