Research progress of pharmacological effects of resveratrol and its derivatives on photodermatoses
Resveratrol (Res),a polyphenolic compound found in natural plants,has various pharmacological activities including anti-inflammatory,antioxidant,anticancer,neuroprotective effects,regulation of lipid metabolism,and improvement of cardiovascular diseases. In recent years,research on the improvement and treatment of skin diseases by natural products and active ingredients has been increasing,and the excellent therapeutic performance of Res in skin diseases has received widespread attention. Studies have shown that Res has good therapeutic effects on photodermatoses caused by ultraviolet light,and this is closely related to signaling pathways such as p38/MAPK/MMP,NF-κB/TNF-α,p53/AMPK,and Nrf2. This paper reviews the effects of Res and its derivatives on anti-inflammation,antioxidation,regulation of autophagy,delaying photoageing,regulation of skin cell immunity,improvement of photoaged skin cancer,and inhibition of skin pathogens,with the premise of ultraviolet protection. It is expected to provide reference for further research on the effects of Res on photodermatoses.
ResveratrolSkin agingSkin inflammation and oxidationAutophagy regulationPigment depositionPhoto-induced skin cancerPharmacological action
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