铁代谢介导的抗抑郁机制及中医药调控研究进展
Study progress of iron metabolism-mediated antidepressant mechanism and the regulation by traditional Chinese medicine
潘雅楠 1陈佳美 2宇庆迎 3邓迪 3张荣 3周丹丹 1曹丽萍2
作者信息
- 1. 广州中医药大学第七临床医学院,广东深圳 518133;广州中医药大学中药学院/国际中医药转化医学研究所,广州 510006
- 2. 广州中医药大学第七临床医学院,广东深圳 518133
- 3. 广州中医药大学中药学院/国际中医药转化医学研究所,广州 510006
- 折叠
摘要
抑郁症患病率逐年攀升,目前发病机制复杂,病因尚未明确.脑铁代谢稳态在中枢神经系统中发挥重要作用,其失衡与抑郁症等精神疾病的发病密切相关.临床及动物研究结果显示,铁过载和铁不足均可诱发抑郁症,而铁不足还可能进一步导致认知障碍.尽管如此,当前对于铁代谢与抑郁症的研究仍处于初期阶段,脑铁稳态失衡引起抑郁症的机制尚未完全阐明.中医药在抗抑郁治疗中展现出显著的临床疗效,尤其在调节铁代谢以治疗抑郁症方面具有巨大潜力.本文综述了铁代谢介导的抗抑郁机制及中医药对其调控研究的进展,旨在为阐明脑铁稳态失衡导致抑郁疾病发生的机制以及中医药在这一领域的开发利用提供新的思路和参考.
Abstract
The prevalence of depression is rising year by year. Currently,the pathogenesis is complex and the etiology has not yet been clarified. Brain iron metabolism homeostasis plays an important role in the central nervous system,and its imbalance is closely related to the development of depression and other psychiatric disorders. Clinical and animal studies have shown that both iron overload and iron deficiency can induce depression,while iron deficiency may further lead to cognitive impairment. Nevertheless,current research on iron metabolism and depression is still in the early stages. The mechanism of depression caused by imbalance of brain iron homeostasis has not been fully elucidated. Traditional Chinese medicine (TCM) has demonstrated a significant clinical efficacy in antidepressant treatment,especially in regulating iron metabolism to treat depression. This article reviews the progress of iron metabolism-mediated antidepressant mechanism and its regulation by TCM,which aims to provide new ideas and references for elucidating the mechanism of cerebral iron homeostasis imbalance that leads to depressive disorders as well as the development and utilization of TCM in this field.
关键词
脑铁代谢/抗抑郁机制/中医药/调控作用/铁调素Key words
Brain iron metabolism/Antidepressant mechanisms/Traditional Chinese medicine/Role of regulation/Hepcidin引用本文复制引用
出版年
2024
NETL
NSTL
万方数据