Ghrelin is a multifunctional peptide hormone that affects several biological functions, which was firstly studied about more than ten years. In addition to mediating GH release through the growth hormone secretagogue receptor (GHS- R) , ghrelin is involved in a series of biological functions including regulation of food intake, sleep, body weight, metabolism of glucose and insulin, gastrointestinal motility, cardiovascular functions, cell proliferation, production of proinflammatory cytokines et al. Recently reported that ghrelin and GHS - Rl a are expressed in key cells of both male and female reproductive organs, and in several species including fishes, birds, and mammals. The objective of this paper was to report the funtion of ghrelin at the level of the hypothalamic - pituitary - gonadal axis that influencing reproduction.
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