染色体易位与女性自然流产关系探讨
Analysis on the relation between balanced translocation of chromosomes and reproductive abnormality
李珺 1王笑盈 1吕攀2
作者信息
- 1. 永康市第一人民医院妇产科,浙江永康321300
- 2. 永康市第一人民医院检验科,浙江永康321300
- 折叠
摘要
目的 研究染色体易位与女性自然流产的关系.方法 对2010年1月～2017年1月在我院妇产科门诊就诊的928例女性自然流产患者行外周血染色体核型分析.结果 928例女性遗传咨询者,共检出染色体易位24例,占2.59％,其中罗伯逊易位11例,相互易位1 3例,临床表现主要为自然流产.女性自然流产患者染色体易位检出率随着流产次数增加而增加,差异具有统计学意义(P＜0.01).结论 染色体易位是导致女性自然流产发生的重要原因之一.
Abstract
Objective:Studying the relation between female of spontaneous abortion and chromosome translocation.Methods:In January 2010-January 2017 in our hospital 928 cases of obstetrics and gynecology clinics women abortion patients with peripheral blood chromosome karyotype analysis.Results:928 cases of genetic counselors,24 cases were detected with chromosome translocation,accounted for 2.59％,including robertsonian translocation in 11 cases,13 cases of reciprocal translocation,clinical manifestation is mainly for the recurrent miscarriage.Women abortion patients with chromosome translocation detection rate increase with the number of abortions,statistically significant difference (P＜ 0.01).Conclusion:Chromosomal translocation is one of the women of the important causes of spontaneous abortion.
关键词
外周血染色体核型分析/染色体易位/自然流产Key words
Peripheral blood karyotype analysis/Chromosome translocation/Spontaneous abortion引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据