Objective:To analyze the chromosome abnormality testing results of the copies with pregnancy history and to provide genetic counseling to the patients with adverse pregnancy history.Methods:The peripheral blood of 1126 couples with pregnancy history,who were genetic consultants of the department of Genetic and Prenatal Diagnosis Center of the First Affiliated Hospital of Zhengzhou University in March 2017,was collected to culture lymphocyte and performed G banding karyotype analysis.Results:Of the 1126 couples with adverse pregnancy history,62 cases were detected as abnormal chromosome;the chromosome abnormality detection rate was 5.51％ (62/1126).Of 62 cases of chromosomal abnormalities,there were 19 cases of balanced translocation,accounting for 30.65％ (19/62),11 cases of Klinefelter's syndrome,accounting for 17.74％ (11/62),10 cases of unknown derived chromosomes,accounting for 16.13％ (10/62),7 cases of robertsonian translocation,accounting for 11.29％ (7/62),6 cases of inversion,accounting for 9.68％ (6/62),3 cases of sex reversal syndrome,accounting for 4.84％ (3/62),2 cases of chimaera,accounting for 3.23％ (2/62),1 case of Turner syndrome,accounting for 1.61％ (1/62),1 case of deletion,accounting for 1.61％ (1/62),1 case of Down's syndrome,accounting for 1.61％ (1/62),and 1 case of superfemale syndrome,accounting for 1.61％ (1/62).Conclusions:Chromosome abnormality is one of the important genetic causes to the adverse pregnancy history;also the other factors should be noted.
NETL
NSTL
维普
万方数据
