Study on the correlation between oxidative stress and recurrent spontaneous abortion
Objective To investigate the etiology and molecular mechanisms of oxidative damage in individuals with recurrent spontaneous abortion(RSA)is of great significance in advancing our comprehension of the pathogenesis of oxidative stress in RSA and providing valuable insights for clinical interventions.Methods In this study,the levels of malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPx),reduced glutathione and oxidized glu-tathione(GSH and GSSG)were evaluated in the peripheral venous blood of 17 cases with RSA and 11 cases with normal early pregnancy.The objective of this study was to analyze the disparities between two distinct groups and explore the potential role of oxidative response in RSA.To accomplish this,GSE26787 and GSE22490 gene microarray data were obtained from the Gene Expression Omnibus(GEO)database.Following this,differential gene analysis and pathway enrichment analysis were performed to assess the significance of oxidative stress pathways.Results The results demonstrated an increase in the expres-sion of MDA,whereas SOD,CAT,and GPx exhibited a decrease in expression.Furthermore,no statistically significant varia-tions were observed in the levels of GSH and GSSG.To investigate further,a pathways enrichment analysis was performed utilizing the recurrent abortion database and gene ontology(GO).This analysis unveiled a noteworthy enrichment of the Bio-logical Process(BP)pathway in GO,emphasizing the role of OS in RSA.Conclusion The pathway discovery provides new research foundations for identifying and diagnosing RSA cases involving oxidative stress.
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