Objective To explore the risk factors and time distribution of lymph node metastasis after radical treatment for different subtypes of cervical cancer(CCA).Methods A total of 162 patients with CCA who received radical surgery in Gansu Provincial Cancer Hospital from February 2017 to February 2020 were selected as the study objects,and were divided into 4 subtypes of squamous cell carcinoma,adenocarcinoma,adeno-squamous cell carcinoma and special type cancer according to pathological types.The relationship between different subtypes and clinical characteristics was explored,and the time distribution of lymph node metastasis after radical surgery for different subtypes of CCA was analyzed.According to whether lymph node metastasis occurred during the follow-up period,patients were divided into metastatic group(n=46)and non-metastatic group(n=116).Factors affecting the occurrence of lymph node metastasis were analyzed,and the most important clinical factors associ-ated with lymph node metastasis were further screened by stepwise regression method,which was used to construct and verify the Nomogram prediction model.Results Patients with different subtypes had significant differences in tumor diameter,clinical stage,histological grade,lymph node metastasis,depth of muscular invasion and positive vascular cancer thrombus(P＜0.05).Specific type of cancer,tumor diameter,clinical stage,histological grade,depth of muscular invasion,and positive thrombus were the risk factors for lymph node metastasis in patients with CCA after radical surgery(P＜0.05).By stepwise regression analysis,four fac-tors were found to be the most correlated with lymph node metastasis,including special type of cancer,tumor diameter,histo-logical grade and clinical stage.The four factors were included and a column diagram was constructed,which showed good dif-ferentiation and accuracy of the model.The risk time of total lymph node metastasis after radical CCA surgery was bimodal,and the peak of metastasis was 12 months and 30 months.Conclusion Patients with CCA were more likely to develop lymph node metastasis after radical surgery,and the risk was highest at 12 and 30 months after surgery.
cervical cancerradical operationlymph node metastasistime distributionNomograph model
NETL
NSTL
万方数据
