Objective To investigate the expression of the NOB1 in cervical cancer patients and its correlation with prognosis.Methods From January 2018 to March 2020,121 cervical cancer patients who underwent surgical treatment in Hubei University for Nationalities Affiliated Minda Hospital were regarded as research subjects,and 121 normal tissue sam-ples from benign cervical diseases were regarded as controls.All clinical basic data such as FIGO staging and lymph node metastasis of cervical cancer patients were collected;the expression of NOB 1 in the two groups was detected.Kaplan-Meier method was applied to analyze the relationship between NOB1 expression in cervical cancer tissue and prognosis.Multivariate Cox regression was applied to analyze the prognostic factors of cervical cancer patients.Results The high expression rate of NOB1 protein in cervical cancer tissue was 71.07％(86/121),which was higher than that in normal cervical tissue,which was 32.23％(39/121)(x2=36.552,P=0.000).The expression of NOB1 in cervical cancer tissue was obviously correlated with clinical pathological features such as FIGO staging,lymph node metastasis,and degree of differentiation(P＜0.05).Kap-lan-Meier method showed that the 3-year survival rate of patients with high NOB1 expression in cervical cancer tissue was 56.98％(49/86),which was lower than 88.57％(31/35)of patients with low NOB1 expression(x2=11.442,P=0.001).Multi-variate Cox regression analysis showed that NOB1,FIGO staging,lymph node metastasis,and degree of differentiation were the prognosis factors of cervical cancer patients(P＜0.05).Conclusion NOB 1 is obviously overexpressed in cervical cancer tissue,which is obviously correlated with clinical and pathological features such as FIGO staging,lymph node metastasis,and degree of differentiation.Patients with high expression of NOB 1 have poor prognosis.Detecting NOB1 level is of great value in predicting the prognostic survival of cervical cancer patients.
Yeast gene Noblp human homologous genecervical cancerprognosiscorrelation
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