首页|2015-2021年滕州市出生缺陷发病趋势的JoinPoint回归分析

2015-2021年滕州市出生缺陷发病趋势的JoinPoint回归分析

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目的 了解滕州市2015-2021年出生缺陷发生现况,为滕州市出生缺陷防控工作提供参考依据.方法 收集滕州市2015-2021年出生的围生儿数据资料,运用JoinPoint模型以平均年度变化百分比(AAPC)和年度变化百分比(APC)来分析出生缺陷发生率变化趋势.结果 滕州市2015-2021年围生儿出生缺陷发生2390例,平均发生率为139.97/万,经JoinPoint模型分析,7年间出生缺陷发生率总体呈上升趋势,平均年度变化百分比(AAPC)为0.6%,该趋势在2017年出现拐点,2015-2017年呈明显的上升趋势,年度变化百分比(APC)为16.50%,2017-2021年呈下降趋势,年度变化百分比(APC)为-6.51%.出生缺陷以男性居多,城镇人口发病率更高,在年龄分布上呈U形分布,母亲≥35岁和<20岁发病率高,在缺陷疾病分布上大体以先天性心脏病、多指/趾、外耳其他畸形最为常见.结论 2015-2021年滕州市出生缺陷的发生率总体呈上升趋势,但2017年之后有下降趋势,出生缺陷防控形势良好.先天性心脏病、多指/趾、外耳其他畸形发生率较高,仍然是防控的重难点.需进一步强化三级预防,科学实施干预措施,最终达到降低出生缺陷发生率的目标.
JoinPoint regression analysis on the incidence trend of birth defects in Tengzhou city from 2015 to 2021
Objective To understand the current situation of birth defects in Tengzhou from 2015 to 2021,and to pro-vide reference basis for the prevention and control of birth defects in Tengzhou.Methods The data of perinatal infants born in Tengzhou from 2015 to 2021 were collected,and the JoinPoint model was used to analyze the change trend of birth defect inci-dence rate with average annual change percentage(AAPC)and annual change percentage(APC).Results There were 2390 peri-natal birth defects in Tengzhou from 2015 to 2021,with an average incidence rate of 1399.7 million.According to the analysis of JoinPoint model,the incidence rate of birth defects in 7 years showed an overall upward trend,with an average annual change percentage(AAPC)of 0.6%.This trend had a turning point in 2017,showing an obvious upward trend from 2015 to 2017,with an annual change percentage(APC)of 16.50%,a downward trend from 2017 to 2021,Annual percentage change(APC)is-6.51%.Birth defects are mostly male,the incidence rate of urban population is higher,and the age distribution is U-shaped.The incidence rate of mothers ≥35 years old and<20 years old is high.In the distribution of defects,congenital heart disease,polydactyly/toe and other malformations of external ear are the most common.Conclusion The incidence of birth defects in Tengzhou city showed an overall upward trend from 2015 to 2021,but there was a downward trend after 2017.The situation of birth defect pre-vention and control was good.Congenital heart disease,polydactyly,and other malformations of the external ear have a high inci-dence,which are still the key and difficult points of prevention and control.It is necessary to further strengthen the three-level pre-vention and scientifically implement the intervention measures to finally achieve the goal of reducing the incidence of birth defects.

birth defectsoccurrence rateJoinPoint modelchange trend

刘燕青、方超、李存宇、钟美琴、李静、李军

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山东省滕州市妇幼保健院妇幼信息管理科,山东滕州 277599

山东省滕州市东郭中心卫生院,山东滕州 277599

出生缺陷 发生率 JoinPoint模型 变化趋势

山东省医药卫生科技发展计划项目

202112031087

2024

中国优生与遗传杂志
中国优生科学协会

中国优生与遗传杂志

CSTPCD
影响因子:0.527
ISSN:1006-9534
年,卷(期):2024.32(1)
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