Objective The genetic etiology associated with patients with oligospermia and azoospermia was explored by analyzing sex hormone levels,Y chromosome AZF microdeletions,and chromosomal karyotyping results in patients with oligospermia and azoospermia.Methods The clinical data of 55 cases of azoospermia and 39 cases of oligospermia were ret-rospectively analyzed,including microdeletion of AZF gene and karyotype of sex hormone,statin B and Y chromosomes,and 32 healthy men were selected as normal control group.Results The levels of LH and FSH in the asospermia group and oli-gospermia group were significantly higher than those in the control group,while the levels of FSH and LH in the asospermia group were significantly higher than those in the oligospermia group,and the difference was statistically significant(P＜0.05).INHB in no-spermia group was significantly lower than that in oligospermia group,the difference was statistically significant(P＜0.05)and there was no significant difference in the levels of other hormones among all groups(P＞0.05).Y chromosome microdeletion was detected in 2 of 39 patients with oligospermia,the deletion rate was 3.6％,and 5 of 55 patients with azospermia were detected,the deletion rate was(9.1％,5/55).There were 39 cases of oligospermia and one case with abnormal karyotype,the abnormal rate was(2.6％,1/39).There were 55 cases of azoospermia and 15 cases of abnormal karyotype,the abnormal rate was(27.3％,15/55).Conclusion The combined examination of serum sex hormone,Y chromosome AZF gene microdeletion and chromosome karyotype analysis can help clinicians to evaluate the spermatogenic function and identify the genetic cause of male infertility patients,and provide a reasonable basis for the follow-up treatment of patients.
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