Hyperglycemia in pregnancy,including pregestational diabetes mellitus,prediabetes mellitus,and gesta-tional diabetes mellitus,is associated with a variety of adverse pregnancy outcomes.However,the status of hyperglycemia and the molecular mechanisms that influence maternal and fetal health are unclear.Cellular senescence has been shown to be an irreversible arrest of cell growth driven by a variety of drivers.This is closely related to the disease and plays a role not only in the repair of damage and tumor suppression,but also in the development of diabetes mellitus.A number of recent studies have revealed that hyperglycemia can induce abnormal trophoblast cell senescence in a variety of ways.Different glycemic meta-bolic states and placental trophoblast cell senescence may influence the development of gestational diabetes mellitus and ma-ternal-fetal outcomes.Therefore,this paper reviews advances in normal pregnancy and placental trophoblast cells senescence,hyperglycemia in pregnancy and abnormal senescence of placental trophoblast cells,senescence of placental trophoblast cells and adverse pregnancy outcomes to understand the molecular mechanism of hyperglycemia in pregnancy from a new perspec-tive.
hyperglycemia in pregnancycellular senescencetrophoblast cellpregnancy outcomes
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