颗粒细胞凋亡影响多囊卵巢综合征患者卵泡闭锁的研究进展
Research progress of granulosa cell apoptosis affecting follicular atresia in patients with polycystic ovary syndrome
徐秋霞 1乔岩岩2
作者信息
- 1. 济宁医学院临床医学院,山东济宁 272000
- 2. 济宁市第一人民医院生殖医学科,山东济宁 272000
- 折叠
摘要
多囊卵巢综合征(PCOS)通过多种复杂的机制影响着女性生育能力,如胰岛素抵抗(IR)、氧化应激、慢性炎症,以及随之而来的高雄激素血症、脂肪因子分泌紊乱等可改变颗粒细胞生存的外部环境,在颗粒细胞受到这些外部因素刺激时,导致B细胞淋巴瘤2(Bcl-2)家族中抗凋亡成员与促凋亡成员比例失调,激活细胞内凋亡通路,主要由线粒体途径介导,通过增加线粒体外膜的通透性,促进线粒体释放多种促凋亡蛋白质如细胞色素c(Cyt c),进入胞质的Cytc随后形成凋亡小体进而级联激活胱天蛋白酶(caspase)家族,使颗粒细胞发生凋亡.一旦颗粒细胞发生凋亡,PCOS患者体内卵泡丧失生物学功能并且卵泡内细胞之间的调控失衡,促使卵母细胞和卵泡膜细胞发生凋亡,最终导致卵泡发生闭锁.本文查阅了大量相关文献,旨在探讨PCOS患者颗粒细胞凋亡与卵泡闭锁的关系及其作用机制.
Abstract
Polycystic ovary syndrome(PCOS)affects female fertility through a variety of complex mechanisms,such as insulin resistance(IR),oxidative stress,chronic inflammation,and subsequent hyperandrogenemia,adipokine secretion disor-der and other factors,changing the external environment for the survival of granular cells.When granulosa cells are stimulated by these external factors,the proportion of anti-apoptotic and pro-apoptotic members in the B-cell lymphoma 2(Bcl-2)family is disproportionally affected,and the intracellular apoptosis pathway is activated,mainly mediated by the mitochondrial pathway.By increasing the permeability of the mitochondrial outer membrane,the mitochondria promote the release of a va-riety of pro-apoptotic proteins such as cytochrome c(Cyt c).Entering the cytoplasm,Cyt c then forms apoptotic corpuscles,which cascade activation of the caspase family and apoptosis of granulosa cells.Once granulosa cell apoptosis occurs,the folli-cles in PCOS patients lose their biological function and the regulation between the cells in the follicle is unbalanced,which pro-motes the apoptosis of oocytes and follicular membrane cells,and eventually leads to the atrexia of follicles.In this paper,we reviewed a large number of relevant literatures to explore the relationship between granulosa cell apoptosis and follicular atresia in PCOS patients and its mechanism.
关键词
多囊卵巢综合征/卵泡闭锁/颗粒细胞凋亡Key words
polycystic ovary syndrome/follicular atresia/granulosa cell apoptosis引用本文复制引用
基金项目
2023年济宁市重点研发计划项目(2023YXNS018)
2022年度山东省医药卫生科技发展计划项目(202201010591)
出版年
2024
NETL
NSTL
万方数据