Objective To investigate the screening,diagnosis,treatment and follow-up of neonatal congenital hypo-thyroidism(CH)in Hengshui city and the problems that need to be improved.Methods The data of 797431 neonates screened from 2004 to 2022 in Hengshui city need to be retrospectively analyzed and summarized.Results There were 423 suspected children among 797431 neonates.273 cases of CH were confirmed by intravenous blood collection and ultrasonography,27 cases were with high TSH,and the incidence was 1:2920.Among 273 children with CH,82 cases were thyroid deletion,hy-poplasia or ectopic,accounting for 30.0%,and 191 cases were with normal thyroid development,accounting for 70.0%.All 273 children with CH received timely early diagnosis and treatment,and thyroid function was detected regularly in children with high TSH.Conclusion Through the screening of neonatal congenital hypothyroidism,the children can get timely and effective treatment.After follow-up combined with the actual situation,the existing problems were found.And it provided a guarantee for improving the quality of the birth population.At the same time,it also better promoted the development and promotion of newborn disease screening.