To investigate the mechanism of resveratrol in preventing hypertension during pregnancy based on network pharmacology and molecular docking
Objective To predict the mechanism of resveratrol in preventing gestational hypertension by network pharmacology and molecular docking.Methods Pharm Mapper,TCMSP and Swiss Target Prediction database were used to obtaine the resveratrol related targets.Targets associated with gestational hypertension were retrieved from GeneCards,Dis-GeNET and OMIM databases.The association network of"Resveratrol-gestational hypertension-signaling"was constructed using Cytoscape3.7.1 software.Core targets were analyzed by GO and KEGG by DAVID.Autodock software was used for molecular docking of key targets and resveratrol.Results 85 intersection targets of resveratrol and gestational hypertension were selected,and the top 10 targets were IL-6,VEGFA,TP53,EGFR,ESR1,CASP3,PTGS2,STAT3,CTNNB1 and PPARG.The 10 core target proteins were well bound to resveratrol.The pathways with high enrichment were mainly lipid and athero-sclerosis,proteoglycan tumor pathway,fluid shear stress and AGE-RAGE signaling pathway in atherosclerosis,endocrine resistance,diabetes complications,etc.Conclusion Resveratrol may regulate key genes such as IL-6,VEGFA and EGFR,thereby interfering with AGE-RAGE and endocrine resistance signaling pathway to achieve the prevention of hypertension in pregnancy.
NETL
NSTL
万方数据
