Expression of miR-29a-3p and FKBP14 in cervical cancer tissue and their prognostic significance
Objective To investigate the expression of microRNA-29a-3p(miR-29a-3p)and FK506-associated pro-tein 14(FKBP14)in cervical cancer tissue and their predictive role in prognosis.Methods Cancer tissues and adjacent tissues of 110 patients with cervical cancer who were hospitalized and operated in Cangzhou Women and Children's Health Hospital from July 2016 to July 2018 were collected.The expression level of miR-29a-3p was detected by qRT-PCR,and the expression of FKBP14 protein was detected by immunohistochemistry.The correlation between miR-29a-3p and FKBP14 expression was determined by Spearman correlation analysis.The relationship between the expression of miR-29a-3p and FKBP14 and prog-nosis was analyzed by Kaplan-Meier method.The influencing factors of prognosis were analyzed by Cox regression analysis.Results Compared with adjacent tissues,the expression level of miR-29a-3p in cervical cancer tissues was decreased,and the positive rate of FKBP14 increased(P＜0.05).The proportion of patients with low miR-29a-3p expression and positive expres-sion of FKBP14 protein in patients with low differentiation,tumor diameter ≥4 cm and FIGO stage Ⅱ was higher than that in patients with medium and high differentiation,tumor diameter＜4 cm and FIGO stage Ⅰ(P＜0.05).The expression levels of miR-29a-3p and FKBP14 in cervical cancer tissues were negatively correlated(P＜0.05).The 5-year survival rate of patients with high expression of miR-29a-3p was higher than that of patients with low expression,and the 5-year survival rate of pa-tients with positive expression of FKBP14 was lower than that of patients with negative expression(P＜0.05).FKBP14 was a risk factor for death,and miR-29a-3p was a protective factor(P＜0.05).Conclusion The low expression of miR-29a-3p and high expression of FKBP14 in cervical cancer tissues are closely related to the 5-year prognosis of patients,and may become biological indicators of prognosis.
cervical cancermicroRNA-29a-3pFK506-associated protein 14prognosis
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