Objective To analyze the relationship between intestinal flora microecology and lipid metabolism in pa-tients with polycystic ovary syndrome(PCOS).Methods Premenopausal women were enrolled between January 2020 and June 2021,including 47 PCOS patients(PCOS group)and 41 healthy women(control group).Serum lipid profiles were measured using an enzyme kit.The intestinal flora of fecal samples were analyzed by 16S rRNA gene amplicon sequencing and data processing.Results The levels of low density lipoprotein cholesterol,total cholesterol and apolipoprotein B were higher in PCOS group,while the level of high density lipoprotein cholesterol were lower(P＜0.05).The total number of OTU in PCOS group was lower than that in control group(137.15±33.47 vs.159.32±36.31,t=2.979,P=0.004)and Shannon index was lower than that in control group(5.46±0.50 vs.5.69±0.49,t=2.173,P=0.033).There were significant differences in 25 kinds of intestinal flora between PCOS group and control group(P＜0.05).By Spearman correlation analysis,Akkermansiaceae,Oscillospiraceae,norank-Clostridia-UCG-014,Christensenellaceae and UCG-010 were most significantly correlated with lipid metabolism indexes(P＜0.05).Conclusion PCOS has abnormal lipid metabolism and abnormal intestinal flora.Imbalance of intestinal flora may exacerbate lipid metabolism disorders in PCOS patients.
polycystic ovary syndromeintestinal floralipid metabolismimbalance of intestinal flora
NETL
NSTL
万方数据
