Correlation of serum amyloid A and procalcitonin expression in perinatal pregnant women with intrauterine infection of Group B Streptococcus and pregnancy outcome
Objective To investigate the correlation of serum amyloid A(SAA)and procalcitonin(PCT)expression in perinatal pregnant women with intrauterine infection of group B Streptococcus and pregnancy outcome.Methods 150 group B Streptococcus(GBS)positive pregnant women in late pregnancy were selected as the positive group,and 50 GBS negative pregnant women were selected as the control group.According to the status of GBS infection,the positive group was divided into GBS colonization group,GBS subclinical infection group and GBS intrauterine infection group.PCT and SAA levels were compared between the positive group and the control group at admission.The levels of SAA and PCT in GBS coloniza-tion group,GBS subclinical infection group and GBS intrauterine infection group were compared.Receiver operator charac-teristic(ROC)curve was used to analyze the efficacy of SAA and PCT in diagnosing the degree of GBS infection in perinatal pregnant women.Pregnancy outcome was compared between positive group and control group.To compare the levels of SAA and PCT in pregnant women with GBS intrauterine infection of different pregnancy outcomes.ROC curve was used to analyze the efficacy of SAA and PCT in diagnosing different pregnancy outcomes in pregnant women infected with GBS.Results The levels of SAA and PCT in positive group were higher than those in control group(P＜0.05).There were significant differences in the levels of SAA and PCT among the three subgroups(P＜0.05).SAA,PCT and their combined diagnosis had significant diagnostic value on the degree of GBS infection(P＜0.05).The incidence of premature rupture of membranes and neonatal infection in positive group was significantly higher than that in control group(P＜0.05).The levels of SAA and PCT in normal pregnancy outcome group were significantly lower than those in adverse pregnancy outcome group(P＜0.05).SAA,PCT and their combined diagnosis had significant diagnostic value for pregnancy outcomes in patients with GBS intrauterine infection(P＜0.05),and the combined diagnosis was superior to the single diagnosis of PCT.Conclusion SAA and PCT in perinatal pregnant women can effectively predict the degree of intrauterine B Streptococcus infection and the pregnancy outcome.
serum amyloid Aprocalcitoningroup B Streptococcus intrauterine infectionpregnancy outcome
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