Premature ovarian failure(POF)is an endocrine disease that seriously affects the physical,reproductive and mental health of women of childbearing age.At present,there is no effective treatment to restore ovarian function.Ovar-ian granulosa cells play an important role in protecting ovarian function.Granulosa cells(GCs)are the basic functional units of ovary,and their proliferation,differentiation and apoptosis directly affect the development of oocytes and follicular matura-tion.In recent years,many studies have shown that mesenchymal stem cells(MSC)and their exosomes(MSC-Exo)promote follicular development and restore ovarian function and fertility in patients with POF by promoting the proliferation of GCs,inhibiting apoptosis,and regulating oxidative stress.In this paper,we summarize and analyze the research progress of MSC and MSC-Exo in regulating ovarian GCs and restoring ovarian function in recent years,deeply explore their related therapeutic mechanisms,evaluate their potential for clinical treatment,and provide a theoretical basis for the further research and clinical application of mesenchymal stem cells in the treatment of POF.
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