Analysis of the functions and clinical prognostic evaluation of TGFBR2 in breast cancer based on bioinformatics
Objective To investigate the expression,functions and prognostic evaluation of transforming growth fac-tor β receptor 2(TGFBR2)in breast cancer.Methods The expression of TGFBR2 in breast cancer and its relationship with clinicopathological features were analyzed by using UALCAN database and GEPIA2 database.Kaplan-Meier plotter database,GEPIA2 database and TIMER2.0 database were used to explore the prognostic evaluation of TGFBR2 in breast cancer and its relationship with breast cancer stem cell markers,immune cells and immune checkpoints.The genes associated with TGFBR2 in breast cancer and the biological processes that are mainly involved in were investigated through the Linked Omics database.Results Compared with normal tissues,the expression of TGFBR2 was downregulated in breast cancer.In Luminal B,Basal-like and HER2-positive breast cancer,patients with higher expression of TGFBR2 had better prognosis.The expression level of TGFBR2 was positively correlated with the expression level of tumor stem cell markers such as CD44 and CD55,but negatively correlated with the expression level of OCT4.Lower TGFBR2 expression predicted the higher level of tumor cell purity and B cell infiltration in the breast cancer microenvironment.The expression level of TGFBR2 was positively relevant to the infiltration level of five immune cells.The expression of TGFBR2 was linked with the expression of PD-1,PD-L1 and CTLA-4 in breast cancer.Linked Omics database suggested that TGFBR2 was involved in the occurrence and development of breast cancer by affecting multiple pathways.Conclusion TGFBR2 might be a potential biomarker for prognosis evaluation and treatment of breast cancer.
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