宫颈癌组织GOLPH3蛋白表达与铂类化疗敏感性的关系分析
Analysis of the relationship between GOLPH3 protein expression and platinum chemotherapy sensitivity in cervical cancer tissue
赵俊哲 1王永花1
作者信息
- 1. 青海红十字医院妇一科,青海西宁 810000
- 折叠
摘要
目的 探究宫颈癌组织高尔基磷酸化蛋白3(GOLPH3)表达与铂类化疗敏感性的关系.方法 选取2017年10月至2020年2月于青海红十字医院就诊的118例宫颈癌患者为研究对象.免疫组化法、Western blot检测GOLPH3表达情况;分析癌组织GOLPH3表达与病理特征的关系;比较不同化疗效果宫颈癌患者组织中GOLPH3阳性表达情况;Kaplan-Meier法探究GOLPH3表达与宫颈癌患者预后关系.结果 宫颈癌组织中GOLPH3阳性表达率[70.34％(83/118)]、蛋白表达量(0.96±0.27)均高于癌旁组织[35.59％(42/118),0.58±0.16](P＜0.05);癌组织GOLPH3表达与FIGO分期、分化程度、淋巴结转移、浸润深度相关;耐药组患者GOLPH3蛋白表达量显著高于敏感组患者(P＜0.05);GOLPH3阳性表达患者3年生存率[72.29％(60/83)]低于阴性表达患者[91.43％(32/35)](P＜0.05).结论 宫颈癌组织中GOLPH3阳性表达率及蛋白质均呈低表达水平,且其蛋白质表达量与铂类化疗敏感性密切相关,GOLPH3可能成为预测宫颈癌患者铂类化疗敏感性的分子标志物.
Abstract
Objective To investigate the relationship between the expression of Golgi phosphorylated protein 3(GOLPH3)and platinum chemotherapy sensitivity in cervical cancer tissue.Methods A total of 118 patients with cervical cancer who visited Qinghai Red Cross Hospital from October 2017 to February 2020 were collected as the study objects.GOLPH3 expression was de-tected by immunohistochemistry and Western blot;to analyze the relationship between GOLPH3 expression and the pathological features in cancer tissues;the positive expression of GOLPH3 in tissues of cervical cancer patients with different chemotherapy ef-fects was compared.Kaplan-Meier method to explore the relationship between the expression of GOLPH3 and prognosis of patients with cervical cancer.Results The positive expression of GOLPH3 in cervical cancer tissue[70.34% (83/118)]and protein expression(0.96±0.27)were higher than that in adjacent tissues[35.59% (42/118),0.58±0.16](P＜0.05).GOLPH3 expression in cervical cancer tissue was correlated with FIGO stages,differentiation levels,lymph node metastasis,and depth of infiltration(P＜0.05).The expres-sion level of GOLPH3 protein in the drug resistant group was obviously higher than that in the sensitive group(P＜0.05).The 3-year survival rate of patients with positive GOLPH3 expression[72.29% (60/83)]was lower than that of patients with negative expression[91.43% (32/35)](P＜0.05).Conclusion GOLPH3-positive expression and protein were at low expression levels in cervical cancer tissues,and its protein expression level is closely related to platinum chemotherapy sensitivity.GOLPH3 may become a molecular marker for predicting platinum chemotherapy sensitivity in cervical cancer patients.
关键词
宫颈癌/高尔基磷酸化蛋白3/铂类化疗/敏感性Key words
cervical cancer/Golgi phosphorylated protein 3/platinum chemotherapy/sensitivity引用本文复制引用
出版年
2024
NETL
NSTL
万方数据