SMG1在卵巢癌组织中的表达及临床意义
The expression and clinical significance of SMG1 in ovarian cancer tissue
胡双烨 1王维 2裴谦凤 1蒋羽欣 1江炜3
作者信息
- 1. 成都市龙泉驿区妇幼保健院病理科,四川成都 610100
- 2. 成都市龙泉驿区妇幼保健院检验科,四川成都 610100
- 3. 四川大学华西第二医院病理科,四川成都 610044
- 折叠
摘要
目的 探讨生殖器形成抑制基因-1(SMG1)蛋白在卵巢癌(OC)组织中的表达及临床意义.方法 收集2018年2月至2020年2月在成都市龙泉驿区妇幼保健院通过手术切除的116例OC组织,110例卵巢良性上皮肿瘤组织及120例因子宫肌瘤切除的正常卵巢组织.SMG1蛋白水平通过免疫组织化学法评估;生存分析行Kaplan-Meier法评估;影响预后的相关因素通过Cox法进行.结果 SMG1蛋白在OC组织中高表达率明显低于卵巢良性上皮肿瘤组织和正常卵巢组织中的阳性表达率(P＜0.05).SMG1蛋白水平与TNM分期、肿瘤分化程度以及淋巴结转移有关(P＜0.05).OC组织中SMG1蛋白高表达组患者3年生存率为69.44％,高于SMG1蛋白低表达组患者(36.25％)(P＜0.05).SMG1蛋白、淋巴结转移、肿瘤分化程度、TNM分期均是OC患者死亡的影响因素(P＜0.05).结论 SMG1蛋白在OC患者组织中低表达,是预测OC患者预后的可靠辅助指标.
Abstract
Objective Exploring the expression and clinical significance of genital formation inhibition gene-1(SMG1)protein in ovarian cancer(OC)tissues.Methods 116 ovarian cancer tissues,110 benign ovarian epithelial tumor tis-sues and 120 normal ovarian tissues removed due to uterine fibroids were collected from February 2018 to February 2020 by surgical resection in Longquanyi District of Chengdu Maternity and Child Health Care Hospital.The level of SMG1 protein was evaluated by immunohistochemistry.Survival analysis was evaluated using the Kaplan-Meier method.The relevant fac-tors affecting prognosis were analyzed using Cox method.Results The high expression rate of SMG1 protein in OC tissue was significantly lower than that in benign ovarian epithelial tumor tissue and normal ovarian tissue,and the difference was statis-tically significant(P＜0.05).The expression level of SMG1 protein was related to the degree of tumor differentiation,TNM staging,and lymph node metastasis in patients(P＜0.05).The 3-year survival rate of patients with high SMG1 protein expres-sion in ovarian cancer tissue was 69.44% ,which was obviously higher than that of patients with low SMG1 protein expression(36.25% )(P＜0.05).SMG1 protein,lymph node metastasis,tumor differentiation,and TNM staging are all influencing factors for mortality in OC patients(P＜0.05).Conclusion SMG1 protein is low expressed in the tissues of OC patients and is a reli-able auxiliary indicator for predicting the prognosis of OC patients.
关键词
卵巢癌/SMG1蛋白/临床病理特征/预后Key words
ovarian cancer/SMG1 protein/clinical pathological characteristics/prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据