Objective Exploring the expression and clinical significance of genital formation inhibition gene-1(SMG1)protein in ovarian cancer(OC)tissues.Methods 116 ovarian cancer tissues,110 benign ovarian epithelial tumor tis-sues and 120 normal ovarian tissues removed due to uterine fibroids were collected from February 2018 to February 2020 by surgical resection in Longquanyi District of Chengdu Maternity and Child Health Care Hospital.The level of SMG1 protein was evaluated by immunohistochemistry.Survival analysis was evaluated using the Kaplan-Meier method.The relevant fac-tors affecting prognosis were analyzed using Cox method.Results The high expression rate of SMG1 protein in OC tissue was significantly lower than that in benign ovarian epithelial tumor tissue and normal ovarian tissue,and the difference was statis-tically significant(P＜0.05).The expression level of SMG1 protein was related to the degree of tumor differentiation,TNM staging,and lymph node metastasis in patients(P＜0.05).The 3-year survival rate of patients with high SMG1 protein expres-sion in ovarian cancer tissue was 69.44% ,which was obviously higher than that of patients with low SMG1 protein expression(36.25% )(P＜0.05).SMG1 protein,lymph node metastasis,tumor differentiation,and TNM staging are all influencing factors for mortality in OC patients(P＜0.05).Conclusion SMG1 protein is low expressed in the tissues of OC patients and is a reli-able auxiliary indicator for predicting the prognosis of OC patients.
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