炎症与血液高凝状态在反复妊娠丢失中的作用
The role of inflammation and hypercoagulability in recurrent pregnant loss
徐梦浩 1朱文馨 1郑翠红1
作者信息
- 1. 华中科技大学同济医学院附属同济医院中西医结合研究所,湖北武汉 430030
- 折叠
摘要
反复妊娠丢失指与同一配偶连续发生2次及以上在妊娠28周之前的妊娠丢失,包括生化妊娠,约1％～5％的夫妇受此疾病困扰.反复妊娠丢失的病因和发病机制复杂多样,目前已知炎症和血液高凝状态是其重要因素.本文回顾了这一领域的现有知识,以3种子宫局部免疫细胞,即子宫自然杀伤细胞、巨噬细胞、T细胞为代表讨论了炎症在反复妊娠丢失中的作用,以及血液高凝状态在反复妊娠丢失中的作用,并讨论了二者的交互作用.本文旨在为未来对反复妊娠丢失的机制研究、诊断和治疗提供思路.
Abstract
Recurrent pregnant loss(RPL)is defined as 2 or more consecutive pregnancy losses with the same partner occurring before 28 weeks of gestation,including biochemical pregnancy,about l% -5% of couples are afflicted with this dis-ease.The etiology and pathogenesis of RPL are complex,with inflammation and hypercoagulability known as important fac-tors.This paper reviewed the current knowledge in this field,discussed the role of inflammation in RPL,represented by three local immune cells—uterine natural killer cells,macrophages,and T cells,discussed the role of hypercoagulability in RPL,and discussed the interaction between inflammation and hypercoagulability.This review aimed to provide thoughts for re-search on mechanisms,diagnosis and treatment of RPL in the future.
关键词
反复妊娠丢失/炎症/血液高凝状态Key words
recurrent pregnant loss/inflammation/hypercoagulability引用本文复制引用
出版年
2024
NETL
NSTL
万方数据