微生物-肠-脑轴在早产儿脑白质损伤中的研究进展
Progress of microbiota-gut-brain axis in white matter injury in preterm infants
李银珊 1刘玲 1林少珠 1罗晗 1敖当1
作者信息
- 1. 广东医科大学附属医院儿科,广东湛江 524000
- 折叠
摘要
早产儿脑白质损伤(WMI)包括脑室周围白质软化(PVL)和脑室周围出血性梗死(PHI),前者是指侧脑室周围白质区域的缺血性坏死,后者是指一种从出血进展到缺血的出血性脑损伤.随着对WMI发病机制的深入了解,肠道微生物群的作用越来越受到关注.肠道微生物作为肠道与神经系统之间重要的沟通媒介,在微生物-肠-脑轴中具有双向调节作用,对脑白质损伤的发生、发展与修复均有影响,然而其确切机制尚不清楚,本文对其研究进展作一综述,为进一步预防和治疗早产儿WMI提供新策略.
Abstract
White matter injury(WMI)in preterm infants encompasses periventricular leukomalacia(PVL)and periventricular hemorrhagic infarction(PHI).PVL refers to ischemic necrosis in the periventricular white matter around the lateral ventricles,while PHI describes hemorrhagic brain injury progressing from hemorrhage to ischemia.With an in-depth understanding of the pathogenesis of WMI,the role of the gut microbiota is gaining attention.The gut microbiota,as a crucial communication media between the gut and the nervous system,has a bidirectional regulatory effect in the microbiota-gut-brain axis on the occurrence,development,and repair of white matter injury.However,the exact mechanisms remain unclear.This review aimed to summarize the research progress,providing new strategies for the prevention and treatment of WMI in pre-term infants.
关键词
早产儿/脑白质损伤/菌群失调/微生物-肠-脑轴Key words
preterm infants/white matter injury/dysbiosis/microbiota-gut-brain axis引用本文复制引用
基金项目
广东省医学科研基金项目(A2022441)
广东医科大学附属医院临床研究项目(LCYJ2019B009)
出版年
2024
NETL
NSTL
万方数据