The relationship between the expression of Cofilin 1,DCTN2 and clinicopathological characteristics,prognosis of breast cancer patients
Objective To investigate the relationship between the expression of Cofilin 1 and DCTN2 and the clini-copathologic features and prognosis of breast cancer(BC)patients.Methods BC patients admitted to the Zhangjiakou First Hospital from November 2015 to November 2019 were selected,and their BC tissues and paracancer tissues were taken during operation,which were the BC group and paracancer group.The expression of Cofilin 1 and DCTN2 in each tissue was detected by immunohistochemical staining.The expression levels of Cofilin1 and DCTN2 were detected by ELISA.BC patients were followed up for a period of three years,Kaplan-Meier curve was applied to analyze the relationship between Cofilin1,DCTN2,and the prognosis of BC patients;and COX regression was applied to analyze risk factors affecting the prognosis of BC pa-tients.Results Compared with the adjacent cancer group,the positive expression rates of Cofilin1 and DCTN2 in the BC group were obviously increased(P＜0.05).Compared with paracancer group,the levels of Cofilin1 and DCTN2 in BC group were significantly increased(P＜0.05).The expression levels of Cofilin1 and DCTN2 were related to lymph node metastasis,tumor differentiation,TNM staging,and distant metastasis(P＜0.05).Correlation analysis showed that the expression of Cofilin1 and DCTN2 in BC group was positively correlated with TNM stage(rs=0.744,0.701,P＜0.001).The cumulative sur-vival rate of Cofilin1 and DCTN2 positive expression patients was obviously lower than that of negative expression patients(P＜0.05).The expression of lymph node metastasis(HR=2.528),Cofilin1(HR=3.084)and DCTN2(HR=3.957)were the prognotic factors of BC patients(P＜0.05).Conclusion The expressions of Cofilin1 and DCTN2 in BC tissues were signifi-cantly increased,which were closely related to clinicopathological features and could be used to evaluate the prognosis of BC patients.
Cofilin1DCTN2breast cancerprognosisclinical pathological features
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