Study on the difference on the proteinuria components between pregnant women with declined eGFR in preeclampsia and chronic kidney disease
Objective To explore the difference on the proteinuria components between pregnant women with de-clined estimated glomerular filtration rate(eGFR)in preeclampsia(PE)and chronic kidney disease(CKD).Methods An ret-rospective study was conducted among 328 pregnant women from July 2016 to December 2022.Results of the eGFR and pro-teinuria components were collected.Results With eGFR≥90 mLL/(min·1.73 m2),serum albumin(sAlb)in CKD was higher than that in PE,while 24 h proteinuria in PE was higher than that in CKD.There was no significant difference on urinary mi-croalbumin(uAlb),transferrin(TRF),α1-microglobulin(α1-MG),β2-microglobulin(β2-MG),and retinol-binding protein(RBP)between PE and CKD.With eGFR＜90 mL/(min·1.73 m2),serum creatine(sCr)in CKD was higher than that in PE,while sAlb in PE was lower than that in CKD.24 h proteinuria in PE was still higher than that in CKD.UAlb in the PE was higher than in CKD,while uβ2-MG and uRBP in PE was significantly lower than in the CKD group.The standard eGFR value of 90 mLL/(min·1.73 m2)was utilized.In the PE group,sAlb levels were higher,while sCr,BUN,24 h proteinuria,uAlb,uTRF and uα1-MG levels were lower in those with an eGFR greater than or equal to this standard compared to those with an eGFR less than this standard.Among the CKD group,sAlb levels were higher in pregnant women with CKD and an eGFR greater than or equal to this standard compared to those with an eGFR less than this standard.However,sCr,BUN,24 h pro-teinuria,uAlb,uTRF,uα1-MG,uβ2-MG,and uRBP levels were lower in CKD group with an eGFR greater than or equal to this standard.Conclusion There was a significant difference in proteinuria components between PE and CKD pregnant women with the declined eGFR levels.The decline of eGFR and appearance of glomerular urine protein in PE is related to hypopro-teinemia,while an elevated level of uα1-MG,uβ2-MG and uRBP indicates the decline of eGFR with elevated sCr in CKD.
preeclampsiapregnancies complicated with chronic kidney diseaseeGFRproteinuria components
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NSTL
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