The association of peripheral T lymphocyte subsets and the risk of decreased ovarian reserve function in patients with ovarian cysts
Objective Explore the relationship between peripheral blood T cell subsets and the decline of ovarian re-serve function in patients with ovarian cysts.Methods A total of 120 patients with ovarian cysts admitted to Jiangyin Hospital of Traditional Chinese Medicine from April 2021 to March 2023 were selected as the study subjects.According to ultrasound diagnosis and hormone measurement,the patients were divided into a group with decreased ovarian function(n=53)and a group with normal ovarian function(n=67).Clinical data of the two groups were compared,and the levels of T lymphocyte subsets and ovarian reserve function indicators were measured.Logistic regression analysis was used to investigate the impact of peripheral blood T lymphocyte subsets on ovarian function decline.The correlation between peripheral blood T lymphocyte subsets and ovarian reserve function decline was explored.The dose-response relationship between peripheral blood T lymphocyte subsets and ovarian reserve function decline was analyzed using spline functions and logistic regression.Results Comparing the peripheral blood T lymphocyte subsets and ovarian reserve-related parameters between two groups of patients,the levels of CD3+,CD8+,FSH,E2,and LH were higher in the group with decreased function than in the group with normal function(P＜0.05),while the levels of CD4+,CD4+/CD8+,AMH,INH-A,INH-B,FSH/LH,T,P,PRL,AFC,and OV were significantly lower in the group with decreased function than in the group with normal function(P＜0.05).The logistic regression analysis results showed that the higher the levels of CD3+and CD8+,the greater the risk of ovarian function decline,and the lower the levels of CD4+and CD4+/CD8+,the greater the risk.The ratios of CD3+,CD4+,CD8+,CD4+/CD8+were significantly corre-lated with FSH,AMH,LH,T and P.In addition,there was a threshold dose-response relationship between CD3+,CD4+,CD8+,CD4+/CD8+and ovarian reserve function in patients with ovarian cysts.Conclusion There is a close correlation between pe-ripheral blood T lymphocyte subsets and the risk of ovarian reserve decline in patients with ovarian cysts.Patients with ele-vated levels of CD3+and CD8+and decreased levels of CD4+and CD4+/CD8+are more likely to experience a decline in ovar-ian reserve.
ovarian cystT lymphocyte subsetovarian reserve functioncorrelation study
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