Research progress on long non-coding RNAs in ovarian dysfunction diseases
Long non-coding RNA(lncRNA)is a class of RNA that does not code for proteins with a length of more than 200 nucleotides,whose expression is tissue-specific,lncRNAs participate in a variety of biological processes such as follicular development,synthesis of reproductive hormones,and the development of ovarian tumors in the ovary.lncRNAs in the cytoplasm regulate mRNA transcription,translation and sponge adsorbed miRNAs as ceRNA,which regulate gene expres-sion mostly in the post-transcriptional level of trans-regulation.Steroid hormones secreted by the ovary are biologically altered in premature ovarian insufficiency,polycystic ovary syndrome and diminished ovarian reserve,among other biological altera-tions.Ovarian granulosa cells interact with oocytes and play an important role in regulating ovarian function.Increasing evi-dence suggests that lncRNAs are expected to be candidate biomarkers and therapeutic targets for the diagnosis and prognosis of ovarian dysfunction-related diseases.In the study of gene expression regulation patterns,it has become essential to combine multiple RNA information for joint analysis of ceRNAs to explore potential regulatory network patterns.
long non-coding RNAovarian granulosa cellsfollicular developmentpremature ovarian insuffiiciencypolycystic ovary syndrome
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