Post-translational modification of FOXP3 in pregnancy:Gene reprogramming and regulatory networks
The maintenance of normal pregnancy requires the mutual regulation of various cells and cytokines,etc.to form a maternal-fetal interface immune microenvironment regulatory network.However,the regulation of cell component changes and genome epigenetic modifications in the maternal-fetal immune micro-environment has attracted extensive atten-tion.Understanding the appropriate transcriptional regulation modes required for normal pregnancy process from the perspec-tive of epigenetic modification is conducive to further exploring new understanding of the pathogenesis of pregnancy compli-cations.Treg cells are endowed with unique processes to rapidly respond to dynamic changes in the immune microenvironment of pregnancy and can regulate gene-specific transcription and translation processes through different mechanisms.We also described the different epigenetic modification levels of Treg cells essential for pregnancy,and detailed the current research status of FOXP3 protein involved in post-translational modification of Treg function regulation.This review mainly explored the action sites of FOXP3 post-translational modification from the aspects of female germ-cell development,embryonic development,fetal growth,normal pregnancy maintenance and pregnancy complications,and attempted to redefine the post-translational modification state of Treg regulated by FOXP3,providing new insights for personalized diagnosis and treatment of pregnancy complications.
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