Hypertensive disorders of pregnancy and neurological disease,a two-sample Mendelian randomization study
Objective To explore the causal relationship between hypertensive disorders of pregnancy(HDP),in-cluding gestational hypertension(GH)and preeclampsia/eclampsia(PE/E),and neurological disease using two-sample Men-delian randomization(MR).Methods Using the aggregated data of published genome-wide association studies,inverse vari-ance weighted(IVW)was adopted as the main analysis method,with the genetic loci associated with HDP as the instrumental variable.To evaluate the causal relationship between HDP and Alzheimer's disease(AD),epilepsy(EP),Parkinson's disease(PD)and migraine.Cochran's Q test,MR-PRESSO,MR-Egger regression and leave-one-out method were used for sensitivity analysis.Results IVW results showed that GH was positively correlated with migraine(OR=1.207,95％CI:1.082-1.346,P=0.0007);no association was found between GH and AD,EP,and PD(OR=0.878,95％CI:0.762-1.012,P=0.073;OR=1.105,95％CI:0.954-1.279,P=0.183;OR=0.988,95％CI:0.743-1.313,P=0.932).PE/E was positively correlated with EP and migraine(OR=1.131,95％CI:1.011-1.266,P=0.031;OR=1.126,95％CI:1.021-1.242,P=0.018);no association was found between PE/E and AD,PD(OR=0.931,95％CI:0.816-1.063,P=0.293;OR=0.970,95％CI:0.807-1.167,P=0.749).Conclusion GH was associated with migraine;PE/E was associated with migraine and EP.
Mendelian randomizationhypertensive disorders of pregnancy(HDP)preeclampsiaeclampsianeu-rological disease
NETL
NSTL
万方数据
