Mendelian randomization study of the causality between sex hormones and eczema
Objective Existing research has identified a connection between sex hormones and eczema,though the results have been inconsistent.This study aims to explore the causal relationship between sex hormones and eczema using a bidirectional two-sample Mendelian randomization approach.Methods Based on data from large-scale genome-wide associa-tion studies(GWAS),single nucleotide polymorphisms(SNP)that are highly correlated with estradiol(E2),testosterone(T),sex hormone-binding globulin(SHBG),and eczema were selected as instrumental variables.The primary analysis was con-ducted using the inverse-variance weighted(IVW)method,supplemented by the simple median method,weighted median method,and MR Egger regression to assess stability.Sensitivity analysis were performed using F-statistics,Cochran Q test,the MR Egger intercept test,and leave-one-out analysis.Causal association was determined using odds ratios(OR)and 95％confidence intervals(95％CI).Results The study found that increased risk of E2 levels are associated with eczema(OR=1.078,95％CI:1.015-1.145,P＜0.05).The F statistical magnitude were all greater than 10,indicating the absence of weak instrumen-tal variables.Cochran Q test indicated some heterogeneity(P＜0.05),leading to the use of the random-effect IVW analysis method.No horizontal pleiotropy was detected in the MR Egger intercept test or leave-one-out analysis(P＞0.05).Conclusion From a genetic perspective,this study found that elevated E2 levels are associated with an increased risk of eczema,suggesting that E2 could potentially serve as a biomarker for early identification of high-risk individuals,provide certain clinical reference for prevention and treatment.
sex hormoneseczemacausal relationship analysismendelian randomization
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