The correlation between Nrf2 expression and placental pathological changes and the degree of brain injury in premature infants
Objective To investigate the correlation between nuclear factor-erythroid 2-related factor 2(Nrf2)ex-pression and placental pathology and the degree of brain injury in premature infants.Methods 150 premature infants born in Xingtai Central Hospital with brain injury were selected as the injury group,and those born in Xingtai Central Hospital were selected as the control group(n=1 50).To explore the correlation between NBNA assessment,Nrf2 gene expression,patho-logical examination,positive degree of placenta Nrf2 and brain injury in children,the influencing factors of brain injury in preterm infants by Logistic analysis,and the diagnostic value of relevant indicators of ROC analysis for brain injury in preterm infants.Results The placental pathological score of the injured group was higher than that of the control group,while the ex-pression of placental Nrf2 gene,positive degree of placental Nrf2 and NBNA evaluation were lower than those of the control group.Spearman correlation analysis showed that the expression level of Nrf2 and positive degree of placental Nrf2 were negatively correlated with brain injury of preterm infants,while the placental pathological score was positively correlated.Logistic regression analysis showed that Nrf2 gene expression level,placental Nrf2 positive degree and placental pathology score were influential factors in the occurrence of brain injury in preterm infants.ROC curve showed that the above three factors had better diagnostic efficacy in the occurrence of brain injury in preterm infants,and the combined diagnostic efficacy was better(P＜0.05).Conclusion The expression level of Nrf2 gene and the pathological changes of placenta were correlated with the degree of brain injury in preterm infants.By monitoring the health status of the placenta and the level of Nrf2 gene expression and the positive degree of Nrf2 in the placenta,it is possible to detect and intervene in time the risk factors that may lead to brain injury.
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