Correlation between serum vitamin D3 levelsand precocious puberty in overweight or obese children and gender differences
Objective To investigate the correlation between serum vitamin D3[25-(OH)D3]levels and precocious puberty in children who are overweight or obese children and gender differences.Methods A total of 205 overweight or obese children diagnosed with precocious puberty from January 2021 to June 2023 in the Department of Pediatrics of Wenzhou Cen-tral Hospital were selected.According to the median body fat percentage,the children were divided into the high body fat percentage group and the low body fat percentage group,another 205 healthy children in the same period were selected as control group.A Logistic regression model was used to analyse the association between 25-(OH)D3 and precocious puberty and the interaction effect with gender.And Pearson's correlation was used to analyse the linear relationship between 25-(OH)D3 and sex hormones.Mann-Whitney U test and Kruskal-Wallis H test were used to analyse sex hormone changes in children aged 6 to 10 years.Results The median body fat percentage of children with precocious puberty was 23.8％.25-(OH)D3 levels were lower in the higher body fat percentage group than in the lower body fat percentage group,and lower in the precocious puberty group than in the control group(P＜0.05).Higher 25-(OH)D3 levels were independently associated with a reduced risk of precocious puberty(Ptrend＜0.001)and were more significant in girls(Pinteraction＜0.05).25-(OH)D3 was negatively correlated with testosterone(TESTO)in the precocious puberty group.In the control group,25-(OH)D3 was nega-tively correlated with luteinizing hormone(LH)and TESTO(P＜0.05).There were no significant differences in sex hormones by age in children with low levels of 25-(OH)D3(P＞0.05).In children with high levels of 25-(OH)D3,there was a significant trend towards higher follicle stimulating hormone(FSH)in boys and LH in girls(P＜0.05).Conclusion Children with preco-cious puberty have lower levels of 25-(OH)D3 than healthy children.Overweight or obesity can exacerbate 25-(OH)D3 loss and accelerate sex hormone secretion and regulation.Girls are more susceptible to puberty initiation.
overweight or obesityvitamin D3precocious pubertysex hormone
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