Current status of single-cell transcriptome sequencing in the pathogenesis of preeclampsia
Preeclampsia is a pregnancy complication unique to pregnancy,which seriously endangers the health of mother and child.It is the main cause of maternal death in the world,and its pathogenesis has not been clarified yet.Tradi-tional RNA sequencing remained at the average level of cell population and ignored cell heterogeneity,which had certain limitations on the changes in cell level and the identification of pathogenic genes in preeclampsia.Single-cell sequencing technology is to detect gene expression information at the level of individual cells,which can distinguish different cell types and their subtypes and understand their differentially expressed genes.This article reviews the research status of single-cell sequencing technology in the pathogenesis of preeclampsia.
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