Objective:A bionic extraction method to determinate the enrichment of corresponding health risk of eight heavy metals(Pb,Cd,Hg,As,Cu,Ag,Sn,and Sb)in Cordyceps sinensis was established was evaluated.Methods:The soluble heavy metals in C.sinensis were extracted by artifi-cial gastric juice and artificial intestinal juice and the enrichement of the heavy mentals was further de-termined by ICP-MS.Target hazard coefficient(THQ)was employed to evaluated the health risk.Re-sults:Good linear relationships of eight heavy metals was calculated in mass concentration ranges(R2>0.997 0),respectively.Averaged recoveries were 84.05%-114.71%(RSD 2.9%-4.9%).The averaged contents of As,Hg,Cu,Cd,Sb,Pb,and Ag in C.sinensis were 12.122,0.644,15.828,0.095,0.027,0.636,and 0.075 mg·kg-1,respectively,in which Sn was not detected.The dissolution rate of As,Hg,Cu,Cd,Pb,and Ag in artificial gastric juice emerged to be higher than in artificial in-testinal juice.The averaged dissolution rate of As,Hg,Cu,Cd,Pb,and Ag in artificial gastric juice was 19.69%-52.62%,The averagde dissolution rate in artificial intestinal juice was calculated asthe range of 0%-16.05%.The dissolution rate of Sb in artificial intestinal fluid was 25.54%,which was higher than that in artificial gastric fluid(14.68%).The results of health risk assessment indicated that the THQ of As,Hg,Cu,Cd,Pb,Ag,and Sb were all less than 1,indicating that the aforementioned eight heavy metals in C.sinensis showed rare posibility to cause obvious health hazards to human body.Conclusion:The established method was simple,accurate,and reliable,the acquired data indicated the established method was apporpriate for the determination and health risk assessment of the afore-mentioned 8 heavy metals in C.sinensis.The enrichment data of 8 heavy metals in C.sinensis and the healthy evaluation results based on the data might provide quantified date for the in-depth study on safty assessment of heavy metals in C.sinensis.