This paper conducted an in-depth analysis of the historical and current applications of Rhi-zoma Paridis,a traditional Chinese medicine,in the treatment of acne by organizing information from the"Compendium of Materia Medica",various medical prescriptions,and modern pharmacological re-search literature.The study revealed that descriptions of Rhizoma Paridis for acne treatment were re-corded as early as in the ancient text"Shennong Bencao Jing".During the Tang Dynasty,Rhizoma Pari-dis began to be used in prescriptions for acne treatment in combination with other medicines,a practice which continued to develop and improve thereafter.A comprehensive examination of both ancient Chi-nese medical texts and modern research findings indicated that Rhizoma Paridis not only had a long his-tory in treating acne but also demonstrated significant therapeutic efficacy.These insights provided an important reference for the further development and application of Rhizoma Paridis resources in the clinical treatment of acne and other skin diseases.