Brucea javanica was one of the traditional Chinese medicines,and its main active chemical com-ponents were quassionoids,which had pharmacological properties such as anti-tumor,anti-inflammatory,and antiviral.This article collected,summarized,and analyzed existing research results on quassionoids compounds,to explore the mechanisms and the structural differences of compounds with anti-inflammatory activity.The substitution of α,β-unsaturated ketones,glycosides,and olefinic bonds on the A,C,and D rings in quassionoids compounds could affect their anti-inflammatory activity.These quassionoids mainly exerted anti-inflammatory effects by regulating the intracellular NF-κB signaling pathway.In addition,they could also suppress the inflammatory response effectively by inhibiting the expression of various pro-inflammatory factors,including TNF-α,IL-6,IL-β,etc..The anti-inflammatory activity of quassionoids might be related to their anti-complement activity,particularly with complement proteins C3a and C5a.
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